NEOGENESIS PIONEERS TRANDERMALS VITAMIN B12 IN SA
The Transdermal delivery and release system provides a highly efficient, safe, and easy to use method for delivering active ingredients and other compounds to the body through intact skin, thereby offering many other advantages over the traditional dosage forms.
The Transdermal System consists of two integral technologies, the delivery and controlled release system and the chemical composition.
Delivery and Controlled Release
The Transdermal infusion of various ingredients into and through the dermis depends on osmosis through and between the squamous cell walls as they are presented in the epidermis and dermis of human tissue. Osmosis is the “flow of ions or molecules through a semi-permeable membrane (cell wall).” The rate and quantity of osmosis of the ingredients are directly dependent upon the size of the individual molecule and he selection and quantity of the specific enhancer. The transdermal patch, consists of ingredients suspended and micro-dispersed in a unique matrix.
All of NeoGenesis health patches utilizes advanced technology based on multi-layered laminated polymeric structure, in which a layer of vinyl chloride copolymer or terpolymer, containing the chemical compound to be released sandwiched between two or more layers of polymeric films. The chemical solution is released from the Transdermal System at a controlled rate by a process of diffusion through the reservoir and one of the outer layers, which can function as a rate controlling membrane.
Patch manufacturers have successfully utilized this unique technology for the development and commercialization of the Nitroglycerine and Nicotine Transdermal Systems and other chemical compounds to meet a variety of therapeutic and other uses.
Why are Transdermal Time-Release Vit B12 Patches Superior to Oral Supplementation?
1. Dosage Strength: Studies have shown that it takes at least 100mg delivered orally to equal a10mg dose delivered by a transdermal time release patch. Or to put it another way, patches deliver 10 times the dosage that comparable supplements taken orally deliver!
2. Patch delivery bypasses the harsh conditions of the digestive system that degrades and destroys much of the original nutrient value of the supplement. Instead of having to withstand exposure to stomach acids, bile, enzymes and degradation by the liver, the active ingredients in our transdermal patches are absorbed directly into the bloodstream.
3. Instant Direct To Bloodstream Delivery: Dietary supplements delivered by patches start to enter the bloodstream as soon as the patch is applied, as compared to a 2 to 4-hour delay with supplements taken orally. The ability of the digestive tract to absorb efficiently does not impact the absorption of active ingredients delivered via the skin.
4. The time-release function of the patch optimizes the benefits of the dietary supplement formula by delivering optimized dosage levels over a 24- hour period. When an oral supplement is absorbed into the bloodstream the body often excretes a large percentage of it as the full dose, delivered at once, is considered unnaturally high by the body.
5. Convenience: What could be easier than applying a patch before bedtime and taking it off before bedtime the following day, instead of remembering to take multiple pills daily? Most oral supplements need to be taken in themornings, some before breakfast, some after breakfast and some more than once a day. Who has the time to fit this complicated regimen into their busy daily schedule?
6. Cyanocobalamin is the most common form of B12 on the market because it is the cheapest form. It is a synthetic form that’s actually bound to a cyanide molecule (yes, cyanide, the poison!). If you have any vitamin B12 supplements, check the ingredients label to see what form of vitamin B12 they contain. If they contain cyanocobalamin, throw them out!
Solutions for vitamin B12 deficiency:
Traditionally, vitamin B12 deficiency was treated with vitamin B12 injections. This is still a common practice and is effective because it bypasses the digestive tract and goes directly into the bloodstream.
However, it has one obvious downside: it requires being injected! As a result, most people aren’t interested in this method. Another problem with B12 injections is that it usually contains the cyanocobalamin form of vitamin B12. This is also the most common form of vitamin B12 found in B12 supplements.
Cyanocobalamin is a cheap, synthetic chemical made in a laboratory. It’s virtually impossible for you to find this form in nature. Low-end vitamin manufacturers use it because it can be bought in bulk and added to products with claims that they “contain vitamin B12!”
What they don’t tell you is that the vitamin is bound to a toxic, poisonous cyanide molecule that must then be removed from your body by your liver. Why take something to improve your health if it is going to strain your liver at the same time?
Cyanocobalamin is also up to 100 times cheaper than the higher quality methylcobalamin, which we’ll talk about below.
As Wikipedia explains: “A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals and supplements, and as a food additive, because of its lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide…” (http://en.wikipedia.org/wiki/Vitamin_B12)
Removing the cyanide molecule from the vitamin and then flushing it out of your body requires using up so-called “methyl groups” of molecules in your body that are needed to fight things like homocysteine (high levels cause heart disease). By taking low quality cyanobalamin, you’re actually stealing methyl groups from your body and making it do more work at the biochemical level. This uses up substances such as glutathione that are often in short supply anyway, potentially worsening your overall health situation rather than helping it. This is one of the reasons why low-grade vitamins may actually be worse for your body than taking nothing at all!
Cyanocobalamin, in summary, is a low-grade, low quality and slightly toxic (due to the cyanide) form of vitamin B12 that’s used by all the cheap vitamin manufacturers. I recommend avoiding it completely. It won’t kill you to take it, of course, but there’s a better solution for B12.
The better choice: Methylcobalamin
The best form of vitamin B12 to supplement with is called methylcobalamin. This is the form that exists in nature, and it is pre-methylated, meaning it’s ready for your biochemistry to put to immediate use.
TAKING VITAMIN B12 AS AN ORAL DOSE IS LARGELY A WASTE OF MONEY, EVEN IF IT’S METHYLCOBALAMIN
As explained by Ed Sharpe: “The coenzyme form of vitamin B12 is known as methylcobalamin or methyl B12. It’s the only form of vitamin B12 which can directly participate in homocysteine metabolism.
In addition, converting homocysteine to methionine via methyl B12 generates an increased supply of SAMe (S-adenosyl methionine), the body’s most important methyl donor.”
Taking vitamin B12 as an oral dose is largely a waste of money, even if it’s the methylcobalamin form. As much as 99% of the B12 you swallow is not even absorbed – it just passes through your body. There is a whole range of digestive complexities that affect B12 absorption, and since most people these days have at least some degree of digestive imbalance, the oral route is mostly ineffective in correcting B12 deficiency.
There are only three effective routes of vitamin B12 administration: by injection; sublingually (dissolved under the tongue); and transdermally
Sublingual absorption is a viable route that also bypasses the challenges of the digestive tract. However, many of the sublingual B12 products also contain cyanocobalamin. The other challenge with the sublingual route is that once again all the vitamin B12 contained in the tablet is delivered to the bloodstream at once, which results in a large portion of the dose being eliminated by the body.
Remember, 1000mcg of vitamin B12 is not usually found in foods, so the body is not able to utilize this large amount of B12 in one dose. To effectively correct vitamin B12 deficiency, the body needs a constant supply of smaller quantities of B12 over several hours.
EACH PATCH DELIVERS 1000 MCG OF METHYLCOBALAMIN IN A STEADY TIME-RELEASE DOSE OVER A 24-HOUR PERIOD
Vitamin B12 injections obviously require injections from a trained medical professional, so few people pursue this route. The injections usually also contain cheap, synthetic cyanocobalamin.
Our revolutionary vitamin B12 patches, utilizing the latest in transdermal technology, addresses vitamin B12 deficiency by supplying 1000mcg methylcobalamin over a period of 24 hours through the skin, thereby ensuring optimal absorption and utilization of this essential nutrient.
Vitamin B12 Deficiency – Who are at risk?
One of the pitfalls of pursuing a healthy diet is that we are sometimes blind to nutrients we may be missing. Perhaps the most significant nutrient that we are at risk of becoming deficient in as a result of a healthy diet is vitamin B12. This essential nutrient plays a crucial role in nerve health and the production of red blood cells that carry oxygen throughout the body.
Vitamin B12 deficiency is especially common among vegetarians and vegans, but it’s also surprisingly common in meat eaters too. Why? Because vitamin B12 can only be absorbed in the small intestine, and due to common intestinal ailments, even many meat eaters who consume high levels of B12 are unable to absorb it. Research has shown that most people have some degree of digestive imbalance, which will lead to poor nutrient absorption, and nutrients that are difficult to absorb are most likely to be severely lacking.
This leads to a series of seemingly “mystery” health symptoms that actually have a simple common cause: vitamin B12 deficiency!
Symptoms of B-12 deficiency
B12 deficiency is shockingly widespread. Studies now
show that up to 40% of the population may be
clinically deficient in vitamin B12.
Here are some of the most common symptoms of
deficiency (do you experience any of these?):
Ø Chest pain or shortness of breath
Ø Fatigue or unexplained weakness
Ø Dizziness, trouble with balance and fainting
Ø Confusion, memory loss or dementia
Ø Coldness, numbness or tingling in the hands and feet
Ø Slow reflexes or diminished nervous system function
Ø Pale skin or yellowing of the skin
Ø Sore mouth and tongue
Ø High Homocysteine
Ø and also: sore muscles, headaches, nausea, heartburn, abdominal bloating, urinary or fecal incontinence, erectile dysfunction, apathy,depression, irritability, paranoia, hallucinations, psychosis, changes in personality and difficulty with balance and walking, In addition, vitamin B12 deficiency can actually cause brain shrinkage, according to a University of Oxford study. Although more work needs to be done, research is already suggesting a link between vitamin B12 deficiency and Alzheimer’s.
Vegans and vegetarians are prone to vitamin B12 deficiency, because typical vitamin B12 sources (meats, yogurt, etc.) are simply not present in their diets. But even meat eaters can be deficient in B12 due to poor digestion. This is especially true for older people who suffer a diminished ability to absorb nutrients in their small intestine. In addition, many chronic medicines, such as diabetes drugs and even pain pills can interfere with B12 absorption, and intestinal parasites can also strongly block its absorption in the gut. Flora imbalance in the digestive tract can also impact negatively on vitamin B12 levels.
Why you should be concerned about your
Vitamin B12 is a vital nutrient to the overall function of the body. It has several essential functions including:
Ø Production and maturation of red blood cells to allow adequate energy production.
Ø Production of the insulating fat layer around nerves.
Ø Protection from neurodegenerative conditions such as Parkinson’s, dementia and depression.
Ø Increased production of dopamine, needed for adequate motivation and intestinal function.
Ø Breakdown and clearance of hormones.
Ø Proper DNA and RNA replication to promote
enhanced healing, recovery and growth.
Are you at risk for a B12 Deficiency?
Here are just a few of the common reasons why you
might be deficient in B12:
Ø Medications such as glucose regulating drugs and hormone replacement therapy, especially estrogen, interfere with B12 absorption.
Ø Antacids reduce the acid in the stomach needed to absorb B12.
Ø Low protein diets decrease the amount of B12 available.
Ø Altered intestinal function from a non-Paleo diet, grain consumption, stress or intestinal infections.
Ø Alcohol increases the excretion of B12 and its cofactors.
Aging results in a decreased ability to produce the necessary constituents such as hydrochloric acid and intrinsic factor needed for B12 uptake.
Ø Reduced absorption can also be related to immune reactions against the cells of the stomach that release intrinsic factor, which plays an integral role in B12 absorption, a condition known as pernicious anemia.
Ø Stress inhibits gastric activity and efficient assimilation of nutrients.
ü Correct form: It contains methylcobalamin (1000mcg per patch)
ü Correct route: It delivers vitamin B12 through the skin, using a small medical-grade patch placed behind the ear.
ü Correct dose: Each patch delivers 1000 mcg of methylcobalamin in a steady time-release dose over a 24- hour period.
ü Synergism: In addition to methylcobalamin, each patch also delivers 400mcg of Folic Acid, which is widely known to work synergistically with methylcobalamin for heart and nervous system health.
Ø Contains no toxic cyanide
Ø Supports production of SA